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Myosin and actin | Circulatory system physiology | NCLEX-RN | Khan Academy

Video vocabulary

four

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US / fɔ:(r) /

UK / fɔr, for /

A1
  • number
  • 4

imagine

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US / ɪ'mædʒɪn /

UK / ɪˈmædʒɪn /

A1
  • verb
  • To think creatively about; form mental picture of

interact

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US / ˌɪntər'ækt /

UK / ˌɪntɚˈækt /

A2
  • verb
  • To talk or do things with each other

contract

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US / 'kɒntrækt /

UK / 'kɑ:ntrækt /

A1
  • noun
  • Legal agreement, e.g. for doing work for money
  • Agreement to pay someone to kill a person
  • verb
  • To become ill as a result of getting a disease
  • To make an agreement for doing work for money
  • To reduce in size, length due to heat loss
  • To reduce the amount of

actually

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US / ˈæktʃuəli /

UK / ˈæktʃuəli /

A1
  • adverb
  • Used to add new (often different) information

bond

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US / bɒnd /

UK / bɑnd /

A2
  • noun
  • Rope, chain or other thing used to tie someone up
  • Closeness that is shared between people or groups
  • Loan that a government must buy back by a set date
  • Written agreement to pay back borrowed money
  • Joint or connection, often using glue
  • verb
  • To develop a close relationship with
  • To become joined or connected, e.g. using glue

use

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US / ju:s /

UK / ju:s /

A1
  • noun
  • Ability to employ something
  • Need to enable it to work
  • Permission to do something with something
  • Act of spending money
  • Operation of a machine for its function
  • verb
  • To have; to eat, drink, consume etc.
  • To need to operate or work
  • To operate a machine, e.g. a computer
  • To treat a person badly
  • To do something with, for a task or purpose

write

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US / raɪt /

UK / raɪt /

A1
  • verb
  • To compose letters and words on paper or a screen
  • To invent or create a computer program
  • To create a song or piece of music

plus

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US / plʌs /

UK / plʌs /

A2
  • noun
  • A benefit or advantage
  • preposition
  • In addition; add
  • In addition to; Indicates a number above
  • Having a value greater than zero

reason

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US / 'ri:zn /

UK / ˈrizən /

A1
  • noun
  • Ability to think about facts and form a judgment
  • Explanation for why something occurred or was done
  • verb
  • To think and make conclusions in a logical manner

after

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US / 'ɑ:ftə(r) /

UK / ˈæftɚ /

A1
  • adverb
  • Later than another time, or behind something
  • conjunction
  • Following something before
  • preposition
  • When an event happened or time has passed

will

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US / wɪl /

UK / wɪl /

A1
  • noun
  • Desire or choice of someone
  • Document saying who gets your money when you die
  • Strong desire to do something; determination
  • Desire to do something; strong wish to do
  • other
  • Used with verbs to express the future
  • verb
  • To leave property to someone after your death
  • To use mental effort to make something happen
  • Am (is, are) likely to do
  • To influence someone to do something
  • To make something happen by strongly wanting it

tail

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US / teɪl /

UK / tel /

A2
  • noun
  • Extended part at the back of an animal's body
  • Back or last part of something e.g. shirt
  • verb
  • To be end of (a march or parade, line)
  • To follow someone secretly and watch what they do

currency

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US / 'kʌrənsɪ /

UK / ˈkɚrənsi, ˈkʌr- /

B1
  • noun
  • Widespread acceptance
  • Money system that a country uses

either

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US / ˈaɪðə(r) /

UK / ˈiðɚ, ˈaɪðɚ /

A1
  • adjecitve
  • One of two (used when there is a choice of two)
  • adverb
  • (After negative statements) likewise, in addition
  • conjunction
  • Used as the first of two connected things
  • determiner
  • Used as the first of two connected things
  • pronoun
  • The one or the other

here

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US / hɪə(r) /

UK / hɪr /

A1
  • adverb
  • In this place; at this location, position or time

myosin

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US / 'maɪəsɪn /

UK / 'maɪəsɪn /

A1
  • noun
  • Commonest protein in muscle; a globulin that combines with actin to form actomyosin

position

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US / pəˈzɪʃn /

UK / pəˈzɪʃən /

A1
  • noun
  • Person's opinion or attitude about something
  • Specific location where someone or something is
  • Where you play or your role on a sports team
  • Person's job or status level
  • Set of conditions affecting what you can (not) do
  • verb
  • To put in a particular location or direction

try

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US / traɪ /

UK / traɪ /

A1
  • noun
  • Act of putting the ball over the rugby goal line
  • verb
  • To make an effort, to attempt to do something
  • To examine someone or something in a court of law
  • To test to see if it is good or you like it
  • To make a person go through hardship; test
  • To examine something to see if it works

sure

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US / ʃʊə(r) /

UK / ʃʊr /

A1
  • adjecitve
  • Having no doubts about something
  • Have confidence in your own words or actions
  • Firmly established or held; being firm or stable
  • Being correct or true
  • adverb
  • What you say to agree willingly

wove

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US / wəʊv /

UK / woʊv /

B1
  • verb
  • To make a cloth or baskets by crossing threads

exactly

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US / ɪgˈzæktli /

UK / ɪɡˈzæktli /

A1
  • adverb
  • No more and no less than; precisely

white

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US / waɪt /

UK / hwaɪt, waɪt /

A1
  • adjecitve
  • Belonging to a race of people with light skin
  • Of the color of fresh snow and milk
  • noun
  • Person's name
  • Lightest color; The color of fresh snow.

phosphate

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US / ˈfɒsfeɪt /

UK / ˈfɑsˌfet /

A1
  • noun
  • A salt or compound used to help grown plants

put

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US / pʊt /

UK / pʊt /

A1
  • phrasal verb
  • to make a light stop shining by pressing or moving a switch
  • verb
  • To move or place a thing in a particular position
  • To rate something in importance or value
  • To write or say something in a certain manner

release

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US / rɪ'li:s /

UK / rɪ'li:s /

A2
  • noun
  • Act of freeing someone from a duty or burden
  • Introduction of a new product, film, book, etc.
  • Relief from sadness, suffering or trouble
  • Act of freeing from a jail, cage, prison, etc.
  • verb
  • To free someone from a responsibility or burden
  • To allow a film, music etc. to be sold/distributed
  • To allow to leave a jail, cage, etc.; let out
  • To let go of something you are holding

spring

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US / sprɪŋ /

UK / sprɪŋ /

A1
  • noun
  • Coil of metal that lessens impact, e.g. on cars
  • Sudden jump from one place to another
  • The time when plants start growing after winter
  • Place where water flows from beneath the ground
  • verb
  • To lessen the impact of something under pressure
  • To jump into the air

two

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US / tu: /

UK / tu /

A1
  • number
  • 2

writing

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US / ˈraɪtɪŋ /

UK / ˈraɪtɪŋ /

A1
  • noun
  • The act of composing letters on paper
  • other
  • To invent or create a computer program
  • verb
  • To compose letters and words on paper or a screen
  • To invent or create a computer program
  • To create a song or piece of music

enzyme

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US / ˈenzaɪm /

UK / ˈɛnzaɪm /

B2
  • noun
  • A protein made by cells

rest

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US / rest /

UK / rɛst /

A1
  • noun
  • Time when one relaxes, sleeps, or is inactive
  • State in which there is a lack of motion
  • Part of something remaining after some was used
  • verb
  • To stop working or avoid activity to recover
  • (Of dead person) to lie in a grave
  • To lean, support or place something against
  • To not be tired because you had enough sleep

rung

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US / rʌŋ /

UK / rʌŋ /

A1
  • verb
  • To draw a circular shape or mark around something
  • To make a loud, noisy constant sound
  • To produce a sound from a bell, alarm or telephone
  • To call someone using a phone

keep

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US / ki:p /

UK / kip /

A1
  • noun
  • Large, strong tower in the middle of a castle
  • Money spent on you so you can live in a place
  • verb
  • To continue doing something; not to stop
  • To stop balls going in a goal in sports
  • To not give back or return something
  • (Of food) to not spoil or not rot
  • To take possession of something to own, e.g. a pet
  • To have and continue to hold something
  • To do something that you have promised or agreed
  • To stay in a certain place or condition
  • To maintain the rules

something

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US / ˈsʌmθɪŋ /

UK / ˈsʌmθɪŋ /

A1
  • adverb
  • In some degree or measure
  • noun
  • a person or thing of some value or consequence
  • pronoun
  • Thing that is not yet known or named
  • Approximately

come

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US / kʌm /

UK / kʌm /

A1
  • verb
  • To arrive at a place
  • (Of mail) to be delivered
  • To move toward someone; go with someone
  • To reach a certain point or state

help

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US / help /

UK / hɛlp /

A1
  • noun
  • Something given to enable a person to do something
  • Assistance given to someone in need
  • Someone who makes something easier or possible
  • verb
  • To act to enable a person to do something; assist
  • To make something better or less difficult

think

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US / θɪŋk /

UK / θɪŋk /

A1
  • verb
  • To have an idea about something without certainty
  • To have an idea, opinion or belief about something

appropriate

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US / ə'prəʊprɪət /

UK / əˈpropriɪt /

A2
  • adjecitve
  • Right or suitable for some situation or purpose
  • verb
  • To set aside money for a specific later purpose
  • To take (money or goods) without permission

call

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US / kɔ:l /

UK / kɔl /

A1
  • noun
  • A order or request for action
  • The sound an animal makes, often when in danger
  • A correct prediction, e.g. a decision in a game
  • A short visit to a place or person
  • A decision by a referee or umpire in a game
  • verb
  • To make a request or order for action
  • (Animal) to make sounds to warn of danger
  • To announce the date of an election
  • To make a judgment about something
  • To give someone or something a name
  • To guess in advance the result or outcome
  • To visit a place or person for a short time
  • To phone someone
  • To speak, announce or shout in a loud voice

far

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US / fɑ:(r) /

UK / fɑr /

A1
  • adjecitve
  • A long way away
  • Being a long way away
  • adverb
  • To a large degree or extent

leave

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US / li:v /

UK / liv /

A1
  • noun
  • Permission to do something
  • Vacation time; time off work
  • verb
  • To go away from; depart
  • To gift property to someone after you die
  • To allow something to continue happening
  • To let something remain unused or available
  • To let something or someone remain somewhere

where

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US / hwɛə /

UK / hwɛr, wɛr /

A1
  • conjunction
  • At or in the place which
  • In whatever place
  • pronoun
  • Word you use to ask the location of something

another

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US / əˈnʌðə(r) /

UK / əˈnʌðɚ /

A1
  • adjecitve
  • One more, but not this
  • determiner
  • One more added
  • pronoun
  • One more (thing)

issue

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US / 'ɪʃu: /

UK / ˈɪʃu /

A2
  • noun
  • Important topic discussed, debated or argued over
  • Single edition of a magazine
  • verb
  • To make something available to be used or sold
  • To deliver a statement, etc. in an official manner

react

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US / rɪ'ækt /

UK / riˈækt /

A2
  • verb
  • To change when mixing with other chemicals
  • To behave or make a change in a particular way

and

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US / ənd /

UK / ənd, ən,ænd /

A1
  • conjunction
  • Used to refer to two or more things
  • Plus; in addition; on top of that
  • Used to introduce an action that follows another

base

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US / beɪs /

UK / bes /

A2
  • noun
  • Place military personnel live, train, and operate
  • Bottom part of an object that touches a surface
  • Unit of counting, e.g. 10 for counting
  • Most important idea or ingredient to add others
  • Origin or start from which something came
  • Main place where an organization or a person works
  • verb
  • To use as the starting point or origin for
  • To have as the main location for (company, etc.)

biological

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US / ˌbaɪəˈlɒdʒɪkl /

UK / ˌbaɪəˈlɑdʒɪkəl /

B1
  • adjecitve
  • Being related to life and living things

guy

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US / ɡaɪ /

UK / ɡaɪ /

A1
  • noun
  • Man; boy; any person

lot

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US / lɒt /

UK / lɑt /

A1
  • noun
  • What happens to a person in life from chance; fate
  • A group of people seen together
  • Item for sale at an auction
  • Small area of land used for a purpose e.g. parking

anything

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US / ˈeniθɪŋ /

UK / ˈɛniˌθɪŋ /

A1
  • pronoun
  • A thing of any kind

along

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US / əˈlɒŋ /

UK / əˈlɔ:ŋ /

A1
  • adverb
  • As a companion; taken with someone
  • preposition
  • At a point on a line

from

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US / frəm /

UK / frʌm, frɑm,frəm /

A1
  • preposition
  • Starting at a particular place, time or level

over

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US / 'əʊvə(r) /

UK / ˈovɚ /

A1
  • adverb
  • Finished; no longer happening
  • Towards the ground/away from a standing position
  • noun
  • A set of six consecutive balls bowled in cricket
  • other
  • Finished
  • preposition
  • Showing the relation when a thing is above another
  • On or covering something
  • Above or across something
  • More than you need
  • From one side to the other
  • In the direction of; toward

molecule

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US / ˈmɒlɪkju:l /

UK / ˈmɑlɪˌkjul /

B2
  • noun
  • Two or more atoms chemically combined

occur

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US / əˈkɜ:(r) /

UK / əˈkɚ /

A2
  • verb
  • To come to pass or to happen

those

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US / ðəʊz /

UK / ðoz /

A1
  • determiner
  • The people or things we are talking about
  • pronoun
  • The objects far from the speaker

just

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US / dʒʌst /

UK / dʒʌst /

A1
  • adjecitve
  • Proper or appropriate; as is deserved
  • Doing or being what is right or fair
  • Legally correct; having enough evidence
  • adverb
  • Almost; nearly
  • Exactly at the time of
  • Exactly (the same as, like)

load

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US / ləʊd /

UK / lod /

A2
  • noun
  • Large, often heavy, amount of a thing to be moved
  • A burden; heavy responsibility
  • Many or much of something; a lot of
  • Items that fill a truck, machine
  • verb
  • To put in items for use (e.g. bullets in a gun)

shade

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US / ʃeɪd /

UK / ʃed /

A2
  • noun
  • Area of darkness when something blocks the light
  • Something that blocks or reduces light
  • Color that is a little darker or brighter than
  • verb
  • To shelter something from direct light
  • To change the truth to deceive or influence
  • To make one part of a picture darker or lighter

talk

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US / tɔ:k /

UK / tɔk /

A1
  • noun
  • Style of speaking
  • Discussion between two countries
  • Giving information in front of people; lecture
  • Saying things or ideas to someone with words
  • verb
  • To make a formal speech about something
  • To say things or ideas to someone with words

stroke

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US / strəʊk /

UK / strok /

B1
  • noun
  • When blood cannot get to brain, causing damage
  • Mark made by a pen, pencil or brush
  • One movement of oars on a boat
  • verb
  • To rub your hand in a caring way on something

head

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US / hed /

UK / hɛd /

A1
  • noun
  • Counter for the number of cattle
  • Natural mental ability or intelligence
  • Leader or person with the greatest authority
  • Mind; mental ability; mental state
  • Side of a coin with a head on it
  • Top part of your body with eyes and a mouth
  • Starting point of something, e.g. a river
  • verb
  • To hit a ball with your head in a game
  • To be first or at the front or top (e.g. a list)
  • To travel or move toward a particular place; To go in a particular direction
  • To become the leader of something
  • To lead or be responsible for something

amazing

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US / ə'meɪzɪŋ /

UK / ə'meɪzɪŋ /

A2
  • adjecitve
  • Surprising in a pleasing way
  • verb
  • To cause wonder; to surprise completely

definitely

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US / ˈdefɪnətli /

UK / ˈdefɪnətli /

A2
  • adverb
  • Without question; beyond doubt

soon

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US / su:n /

UK / sun /

A1
  • adverb
  • At a time not long from now

depend

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US / dɪˈpend /

UK / dɪˈpend /

B1
  • verb
  • Be controlled or determined by (someone/something)

start

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US / stɑ:t /

UK / stɑrt /

A1
  • noun
  • First time or place that a thing exists; beginning
  • First opportunity to achieve something, e.g. a job
  • Sudden action or movement because you are scared
  • other
  • Beginning of something in place or time
  • verb
  • To do, be or happen for the first time; begin
  • To turn something on

well

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US / wel /

UK / wɛl /

A1
  • adjecitve
  • Being in a fortunate, good condition or state
  • Healthy and in good condition
  • adverb
  • In an acceptable, proper, or successful manner
  • In a complete, total, or full manner
  • A great and considerable degree
  • In a successful way, in a good or satisfactory way
  • exclamation
  • Used to begin or continue a particular statement
  • Used to show you want to start saying something
  • Used to express that you are waiting for a reply
  • You say this to change the topic of a conversation
  • Used to indicate you are making a final remark
  • noun
  • Long deep hole in the ground to get water
  • verb
  • To cause your eyes to fill with tears

system

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US / 'sɪstəm /

UK / ˈsɪstəm /

A1
  • adjecitve
  • Working in an organized, logical way
  • noun
  • Set of organized, planned ideas that work together

for

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US / fə(r) /

UK / fɔr,fə /

A1
  • preposition
  • Used to show the purpose, or need of something

why

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US / waɪ /

UK / hwaɪ, waɪ /

A1
  • adverb
  • Question word to ask for a reason
  • exclamation
  • (Used to express surprise or approval)

wind

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US / wɪnd /

UK / wɪnd /

A1
  • adjecitve
  • (Musical instruments) that you blow into to play
  • noun
  • A current of air moving approximately horizontally, especially one strong enough to be felt
  • Something that has influence
  • verb
  • If a road, path, or river winds, it follows a route that turns repeatedly in different directions
  • To turn or cause something to turn
  • To twist around something

atp

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US / ˌeɪ tiː ˈpi /

UK / ˌeɪ tiː ˈpi /

A1
  • abbreviation
  • ATP is an acronym

take

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US / teɪk /

UK / tek /

A1
  • noun
  • Filming of a single scene for TV or the movies
  • verb
  • To accept something that is offered
  • To use a method of traveling, e.g. a bus or train
  • To use a camera to make (a photo)
  • To pick up something and go away with it
  • To study a subject in school
  • To attempt to pass (an exam)
  • To require a certain amount of time, money, space

change

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US / tʃeɪndʒ /

UK / tʃendʒ /

A1
  • noun
  • Exchange of one set of clothes for another
  • Money in the form of coins instead of paper
  • Money returned after giving too much
  • Act of making or becoming something else
  • verb
  • To exchange one set of clothes for another
  • To exchange one kind of money for another
  • To replace something with another thing
  • To make or become something else
  • To go from one train, bus, etc. and go to another

gee

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US / dʒi: /

UK / dʒi /

C2
  • exclamation
  • Give a command to a horse to turn to right
  • Used to express concern or surprise

bit

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US / bɪt /

UK / bɪt /

A1
  • noun
  • Device put in a horse's mouth to control it
  • Small piece of something
  • verb
  • (E.g. of fish) to take bait and be caught

look

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US / lʊk /

UK / lʊk /

A1
  • noun
  • Person's beauty or physical attractiveness
  • Particular style of dress, clothes, or appearance
  • The way someone, something appears to be
  • Act of searching for or examining something
  • verb
  • To appear to be; seem

all

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US / ɔ:l /

UK / ɔl /

A1
  • adverb
  • Completely; totally
  • determiner
  • Being every one of something
  • pronoun
  • 100% of something; the complete amount

engine

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US / 'endʒɪn /

UK / ˈɛndʒɪn /

A2
  • noun
  • Machine that changes energy into mechanical motion
  • The part of a train that pulls railway cars

its

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US / ɪts /

UK / ɪts /

A1
  • adjecitve
  • Referring to or belonging to ‘it’
  • determiner
  • Of something; belonging or related to something
  • other
  • Possessive form of “it”

produce

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US / prə'dju:s /

UK / prəˈdus, -ˈdjus, pro- /

A1
  • noun
  • Fresh foods such as fruits and vegetables
  • verb
  • To grow something naturally
  • To make something appear
  • To manufacture something using machines
  • To control the making a movie or television show

movement

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US / ˈmu:vmənt /

UK / ˈmuvmənt /

A2
  • noun
  • Part of a piece of classical music
  • Group with a shared interest or goal
  • Group sharing the same idea to change society, art
  • Action you do when exercising, e.g. in a gym
  • Part of a piece of music

pretty

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US / 'prɪtɪ /

UK / ˈprɪti /

A1
  • adjecitve
  • Being attractive to the eye in a simple way
  • adverb
  • Very; to a great degree

spark

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US / spɑ:k /

UK / spɑrk /

B1
  • noun
  • Small piece of burning material produced by fire
  • Tiny, brief bit of light caused by electric energy
  • First small part of an idea or feeling
  • verb
  • To make tiny, brief bits of light
  • To start something new; To set in motion, activate

stimulate

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US / 'stɪmjʊleɪt /

UK / ˈstɪmjəˌlet /

B1
  • verb
  • To arouse or excite emotionally

build

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US / bɪld /

UK / bɪld /

A1
  • noun
  • Your physical shape; physique
  • verb
  • To establish e.g. a reputation, over time
  • To construct a house, office, factory

crawl

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US / krɔ:l /

UK / krɔl /

B1
  • noun
  • Very slow progress (e.g. traffic)
  • Swimming by moving your arms forward then back
  • verb
  • To move very slowly or cautiously
  • To move along with the body close to the ground
  • To walk like an insect

naturally

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US / ˈnætʃrəli /

UK / ˈnætʃərəli, ˈnætʃrə- /

A2
  • adverb
  • In the expected or usual way
  • Without the aid of someone or something

work

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US / wɜ:k /

UK / wɚk /

A1
  • adjecitve
  • Activity completed in order to make money
  • noun
  • The product of some artistic or literary endeavor
  • Everything created by an author, artist, musician
  • Activity you do in order to make money
  • Place of employment
  • Final product or result of a some labor or effort
  • verb
  • To bring into a specific state of success
  • To be functioning properly, e.g. a car
  • To do your job in your company or workplace
  • To make an effort to do something
  • To operate a machine or device

move

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US / mu:v /

UK / muv /

A1
  • noun
  • Act of moving a playing piece in chess, etc.
  • An action; doing something
  • Step taken to achieve a goal
  • verb
  • To cause someone to have certain emotions
  • To cause something to change to a different place
  • To change where people live or a business operates
  • To take action to do or achieve something

way

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US / weɪ /

UK / we /

A1
  • adverb
  • Used to emphasize the amount of something
  • noun
  • Particular aspect of something being thought about
  • One of various choices that could be made
  • Particular existing condition or state
  • (Often long) distance or length of time
  • How something is done
  • Route to go to a place
  • Small street
  • Usual behavior, emotions or habits of someone

everything

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US / 'evrɪθɪŋ /

UK / ˈɛvriˌθɪŋ /

A1
  • pronoun
  • All of the things mentioned

original

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US / ə'rɪdʒənl /

UK / əˈrɪdʒənəl /

A2
  • adjecitve
  • Being first made, thought or performed; fresh
  • Being unique or thinking differently from others

they

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US / ðeɪ /

UK / ðe /

A1
  • pronoun
  • Two or more people, animals, or things

very

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US / 'verɪ /

UK / ˈvɛri /

A1
  • adjecitve
  • Concerning a large degree or amount
  • adverb
  • A lot; much; many
  • Used to stress or emphasize a noun

image

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US / 'ɪmɪdʒ /

UK / ˈɪmɪdʒ /

A2
  • noun
  • Picture, sculpture or painting of something
  • General idea or opinion of something
  • verb
  • To obtain pictures by scanning them with a machine

make

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US / meɪk /

UK / mek /

A1
  • noun
  • Product made by a particular company; brand
  • verb
  • To arrange or prepare something e.g. dinner
  • To get to (a place) on time
  • To gain the status of (teacher, lawyer, etc.)
  • To create something by putting things together
  • To earn a certain amount of money at a job
  • To cause or force a person to do something
  • To cause something to happen or be formed

outside

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US / ˌaʊtˈsaɪd /

UK / aʊtˈsaɪd, ˈaʊtˌsaɪd /

A2
  • adverb
  • Beyond the limits or edges of some place, thing
  • noun
  • Area around or near something, such as a building
  • preposition
  • Beyond the limits or edges of some place, thing

into

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US / 'ɪntə /

UK / ˈɪntu /

A1
  • preposition
  • Moving or going inside something
  • In the same direction as; in the direction of
  • So as to become; taking the state of

other

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US / 'ʌðə(r) /

UK / ˈʌðər /

A1
  • adjecitve
  • A thing different from that mentioned
  • determiner
  • (Something) else; not the first (one)
  • pronoun
  • Being the one and only thing of that category

power

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US / 'paʊə(r) /

UK / ˈpaʊɚ /

A1
  • noun
  • Legal or official right to perform certain actions
  • Ability to move forcefully and quickly
  • Energy of something (e.g. electricity or fuel)
  • Mathematical way to multiply a number
  • Condition of being in political control
  • Physical force, energy, and strength
  • verb
  • To give energy to something, e.g. by electricity
  • To move something forcefully and quickly

one

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US / wʌn /

UK / wʌn /

A1
  • pronoun
  • You; we; people in general; someone
  • The thing or person previously referred to
  • adjecitve
  • Used to refer to people generally
  • Being a strong example of (something mentioned)
  • number
  • Number 1

pull

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US / pʊl /

UK / pʊl /

A1
  • noun
  • Act of breathing in smoke, as from a pipe
  • Force something has that draws other things to it
  • Using your hands to move something to you
  • verb
  • To breathe in smoke, as from a pipe
  • To hold something and move it toward you
  • To remove something by force

relative

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US / ˈrelətɪv /

UK / ˈrɛlətɪv /

A2
  • adjecitve
  • Measured or considered in comparison to another
  • (Grammar) referring to words that appear earlier
  • noun
  • Members of the family
  • Humans or animals sharing the same family history

three

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US / θri: /

UK / θri /

A1
  • number
  • Number 3

big

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US / bɪɡ /

UK / bɪɡ /

A1
  • adjecitve
  • Popular
  • Serious
  • Large

little

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US / 'lɪtl /

UK / ˈlɪtl /

A1
  • adjecitve
  • Being short in length of time
  • Not great in size, amount, or degree; small
  • Being very young or younger than others
  • adverb
  • By an amount or degree that is not very much
  • Not often; rarely
  • noun
  • A person's name

let

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US / let /

UK / lɛt /

A1
  • verb
  • To allow someone to do something
  • Introducing a suggestion to do something together
  • To rent a house, etc. to others

might

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US / maɪt /

UK / maɪt /

A1
  • other
  • Used to politely request an action
  • Used to express that something could happen
  • Power, strength, force or influence

the

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US / ðə /

UK / ðə /

A1
  • article
  • Used to refer to something already mentioned
  • Used to show there is only one of something
  • determiner
  • Used to describe all of a family

adenosine

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US / ə'denəsi:n /

UK / ə'denəsɪn /

A1
  • other
  • (biochemistry) a nucleoside that is a structural component of nucleic acids; it is present in all li

chemical

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US / ˈkemɪkl /

UK / ˈkɛmɪkəl /

A2
  • adjecitve
  • Made of various elements
  • noun
  • Basic substance produced by mixing elements

state

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US / steɪt /

UK / stet /

A1
  • adjecitve
  • Concerning region within a country
  • noun
  • Region within a country, with its own government
  • Situation or condition something is in
  • verb
  • To say; declare as fact

ready

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US / 'redɪ /

UK / ˈrɛdi /

A1
  • adjecitve
  • Being likely or about to do something
  • Being willing to do a task
  • verb
  • To prepare something for use or action

this

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US / ðɪs /

UK / ðɪs /

A1
  • adjecitve
  • Used to indicate something already been discussed
  • Used to indicate something happening around now
  • adverb
  • An indication by a physical motion or gesture
  • A specific amount of
  • determiner
  • Person, thing, or idea near you
  • pronoun
  • Person, thing that has already been discussed

detach

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US / dɪˈtætʃ /

UK / dɪˈtætʃ /

B1
  • verb
  • To send away a military unit on a special mission
  • To separate something from something larger

kind

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US / kaɪnd /

UK / kaɪnd /

A1
  • adjecitve
  • In a caring and helpful manner
  • friendly and considerate
  • noun
  • One type of thing

how

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US / haʊ /

UK / haʊ /

A1
  • adjecitve
  • To what degree? in what amount?
  • adverb
  • (Used to explain the way to do something)
  • exclamation
  • For what purpose or reason?
  • (Used to ask someone or something's condition)

you

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US / jʊ /

UK / ju /

A1
  • pronoun
  • Person someone is speaking or writing to
  • Person or people in general

core

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US / kɔ:(r) /

UK / kɔr, kor /

A2
  • noun
  • Important central part of something
  • verb
  • To take out the central section of a fruit

but

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US / bət /

UK / bʌt,bət /

A1
  • conjunction
  • Used before you say something different, opposite

good

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US / ɡʊd /

UK / ɡʊd /

A1
  • adjecitve
  • Proper, appropriate or right
  • (Of an amount) enough; plenty
  • Excellent; high quality
  • Acting well or properly; of moral character
  • In a positive or happy emotional state
  • noun
  • Advantage or benefit

give

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US / ɡɪv /

UK / ɡɪv /

A1
  • noun
  • Degree of flexibility in something, a material
  • verb
  • To hand over or present something to someone
  • To cause someone to have or experience something

wound

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US / waʊnd /

UK / waʊnd /

A2
  • noun
  • Sadness or displeasure caused by a bad memory
  • Physical injury, especially that suffered in war
  • verb
  • To rotate a part of say a watch to make it work
  • To hurt someone emotionally
  • To injure someone in a fight with a knife gun etc.

copy

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US / ˈkɒpi /

UK / ˈkɑ:pi /

A1
  • noun
  • A counter for items that are the same
  • Fake product pretending to be an original
  • An imitation of an original
  • A duplicate of a paper printed in a photocopier
  • Written text for printing, use in ads, etc.
  • verb
  • To make something look the same as the original
  • To act in the exact same way as someone else
  • To read and then write down what you read

can

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US / kæn /

UK / kən,kæn /

A1
  • noun
  • A metal container for storing food
  • other
  • Able to; have the skill to; have the time to
  • verb
  • To have permission to
  • To be possible to do
  • To preserve food by sealing it in a metal container

conjunction

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US / kənˈdʒʌŋkʃn /

UK / kənˈdʒʌŋkʃən /

B1
  • noun
  • Combination of things or events
  • Word that joins parts of a sentence, e.g. 'and'

really

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US / ˈri:əli /

UK / ˈriəˌli, ˈrili /

A1
  • adverb
  • Used to stress something that is said; definitely
  • In a true or accurate manner
  • Very

understand

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US / ˌʌndə'stænd /

UK / ˌʌndɚˈstænd /

A1
  • verb
  • To know the meaning of language, what someone says

would

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US / wʊd /

UK / wʊd /

A1
  • other
  • Used to indicate something imagined
  • Used to ask or request something politely
  • Verb used to indicate possibility, request etc.
  • Used to indicate a preference
  • Used to indicate a reaction
  • Indicates something that occurred repeatedly
  • Used to indicate willingness or ability to do

intertwine

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US / ˌɪntə'twaɪn /

UK / ˌɪntɚˈtwaɪn /

A1
  • verb
  • To wind together; to cause to be wound together

video

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US / 'vɪdɪəʊ /

UK / ˈvɪdiˌo /

A2
  • adjecitve
  • Of a moving film, with sound
  • noun
  • Recording capturing action with sound
  • verb
  • To make a moving film of, with sound

want

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US / wɔnt /

UK / wɑnt, wɔnt /

A1
  • noun
  • Something you desire or wish for
  • State or condition of poverty
  • verb
  • To desire or wish for something; hope for a thing

fix

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US / fɪks /

UK / fɪks /

A2
  • noun
  • Answer to a problem
  • verb
  • To arrange or prepare something
  • To attach something so it will not move or change
  • To dishonestly arrange the result of a game
  • To make an animal unable to produce young
  • To make something whole or able to work again

not

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US / nɒt /

UK / nɑt /

A1
  • adverb
  • Word indicating the negative
  • (Used to form the negative of verbs)

our

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US / 'aʊə(r) /

UK / aʊr /

A1
  • determiner
  • Belonging to us

attain

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US / əˈteɪn /

UK / əˈten /

B1
  • verb
  • To reach a desired level or amount over time

deal

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US / di:l /

UK / dil /

A1
  • verb
  • To cope with something - usually troubles
  • To give (something bad e.g. news) to
  • To buy and sell illegal drugs
  • To give out (cards, etc.) to; distribute
  • To do business with someone or to sell products

now

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US / naʊ /

UK / naʊ /

A1
  • adverb
  • At the present time or moment
  • Right away or in the next possible moment
  • Used to refer to something that just happened
  • Time between the present and a moment in the past
  • conjunction
  • Resulting from or because of something

nerve

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US / nə:v /

UK / nɚv /

A2
  • noun
  • Fibers in the body that enable feeling, movement
  • Courage to do something that is difficult or risky

protein

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US / ˈprəʊti:n /

UK / ˈprəʊˌtiːn /

B1
  • noun
  • Group of molecules made from amino acids

structure

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US / ˈstrʌk.tʃə /

UK / ˈstrʌk.tʃɚ /

A2
  • noun
  • The way in which the parts of a system or object are arranged or organized, or a system arranged in
  • verb
  • To plan, organize, or arrange the parts of something

become

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US / bɪ'kʌm /

UK / bɪˈkʌm /

A1
  • verb
  • To begin to be; grow to be; develop into
  • To be suitable for a particular job or role

attach

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US / ə'tætʃ /

UK / əˈtætʃ /

A2
  • verb
  • To be associated or connected with

same

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US / seɪm /

UK / sem /

A1
  • adjecitve
  • Being equal in quality and amount
  • Identical; not different
  • Not changing; constant

cell

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US / sel /

UK / sɛl /

A2
  • noun
  • Smallest unit of living things in biology
  • Group of people - often from a secret organization
  • Prisoner's room in a jail
  • Shortened form of 'cellphone'

each

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US / i:tʃ /

UK / itʃ /

A1
  • determiner
  • Every one of two or more things
  • pronoun
  • Per one person or thing

happen

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US / 'hæpən /

UK / ˈhæpən /

A1
  • verb
  • To take place or occur

hydrolyze

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US / ˈhaɪdrəlaɪz /

UK / haɪdrəˌlaɪz /

A1
  • noun
  • Undergo hydrolysis; decompose by reacting with water

fundamentally

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US / ˌfʌndəˈmentəli /

UK / ˌfʌndəˈmɛntl:ɪ /

B1
  • adverb
  • In a basic and important way

essentially

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US / ɪˈsenʃəli /

UK / ɪˈsenʃəli /

A2
  • adverb
  • Basically; (said when stating the basic facts)

fascinating

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US / ˈfæsɪneɪtɪŋ /

UK / ˈfæsəˌnetɪŋ /

B1
  • adjecitve
  • Having your attention fixated as though by a spell
  • Very interesting
  • verb
  • To attract or interest greatly

right

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US / raɪt /

UK / raɪt /

A1
  • adjecitve
  • Correct or true
  • The south side of you looking at the rising sun
  • adverb
  • Exactly in a place or time
  • Being appropriate for a particular event
  • In a straight or direct manner
  • noun
  • Something you are legally or morally allowed to do
  • Ideal of what is just and good
  • Political view based on conservatism
  • verb
  • To fix something previously wrong or unjust
  • To make upright, as a boat that has turned over

touch

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US / tʌtʃ /

UK / tʌtʃ /

A1
  • noun
  • Certain way of doing that makes something special
  • A small amount of something
  • Feeling of a surface
  • verb
  • To affect feelings, especially by causing sympathy
  • To be next to each other with no space between
  • To get involved with (used in negative)
  • To feel an object with your fingers, etc.

adp

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US / /

UK / /

A1
  • other

energy

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US / 'enədʒɪ /

UK / ˈɛnədʒi /

A2
  • noun
  • Physical or mental strength

find

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US / faɪnd /

UK / faɪnd /

A1
  • noun
  • Object discovered by chance
  • Things that have been discovered from searching
  • verb
  • To become aware of something that is happening
  • To discover or meet by chance
  • To decide if someone is guilty of a crime, or not
  • To learn through study, research, or effort
  • To discover something by looking for it

mean

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US / mi:n /

UK / min /

A1
  • adjecitve
  • Being good at
  • Nasty; unkind
  • Not liking to spend money; cheap; stingy
  • noun
  • Average of a set of numbers
  • verb
  • To express a particular idea or thought
  • To intend to do something in particular
  • To have a particular meaning or value

action

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US / 'ækʃn /

UK / ˈækʃən /

A2
  • noun
  • Something that a person or thing does
  • verb
  • To act to do something

first

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US / fɜ:st /

UK / fɚst /

A1
  • adjecitve
  • 1st; Coming before all others in time or place
  • noun
  • Something that has not happened before
  • Position of the winner of a competition

get

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US / ɡet /

UK / ɡɛt /

A1
  • verb
  • To become affected by illness or disease
  • To begin to feel or understand an emotion or idea
  • To send or bring someone or something home, etc.
  • To go somewhere to obtain something
  • To (cause to) do a particular thing
  • To obtain, receive or be given something
  • To currently have
  • To prepare for use
  • To understand something being said or read

tell

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US / tel /

UK / tɛl /

A1
  • verb
  • To (strongly) advise a person to do something
  • To be able to guess
  • To say or communicate information to someone
  • To inform, but without speaking; indicate
  • To have a negative effect on someone
  • To order someone to do something; command
  • To recognize something based on certain signs
  • To report something to an authority
  • To explain something or teach someone something

down

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US / daʊn /

UK / daʊn /

A1
  • adjecitve
  • Being sad, sick, or unhappy
  • Not operating, working, or functioning as expected
  • adverb
  • In a sitting or lying position
  • Towards or on the ground, floor, or bottom
  • Written or copied onto a piece of paper or book
  • noun
  • A period of play in American Football
  • The soft, smooth hairs that cover a bird's body
  • preposition
  • Along something's path, course, or direction
  • Going from a higher position to a lower position
  • verb
  • To eat or drink very quickly and without stopping

then

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US / ðen /

UK / ðɛn /

A1
  • adverb
  • A time that is not now
  • Following another thing in time or arrangement
  • Following on reasonably from what was just stated
  • At that time, not now

scroll

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US / skrəʊl /

UK / skroʊl /

B2
  • noun
  • A long rolled piece of paper with writing on it
  • Something shaped like a rolled piece of paper
  • other
  • To move up, down, or across a computer screen
  • verb
  • To move up and down a computer screen

step

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US / step /

UK / stɛp /

A1
  • noun
  • Movement done as part of a particular dance
  • Distance covered by one movement of a leg; stride
  • One part or stage in a process
  • Sound made by the feet while walking; footstep
  • Flat horizontal piece that forms stairs
  • verb
  • To raise and moving the foot to put it down

cause

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US / kɔ:z /

UK / kɔz /

A2
  • noun
  • Belief, goal or organization that people support
  • Reason for
  • verb
  • To make something happen; create effect or result

place

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US / pleɪs /

UK / ples /

A1
  • noun
  • Particular location, area or region
  • verb
  • To put someone in a particular type of situation
  • To put something in a certain location or position

about

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US / ə'baʊt /

UK / əˈbaʊt /

A1
  • adverb
  • To be ready to; going to
  • Nearly; approximately; roughly
  • Near; next to; close to
  • In every direction; in the area of
  • preposition
  • Concerning or of (a topic)

like

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US / laɪk /

UK / laɪk /

A1
  • adjecitve
  • Being equal in status or kind to something else
  • Similar; the same
  • adverb
  • For example
  • preposition
  • Used as a filler; used to ad emphasis
  • In a way similar to the way something is done
  • Such as; for example
  • verb
  • To want to
  • To find something pleasing; to prefer something

people

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US / 'pi:pl /

UK / ˈpipəl /

A1
  • noun
  • Persons sharing culture, country, background, etc.
  • Men, Women, Children

sit

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US / sɪt /

UK / sɪt /

A1
  • verb
  • To take an exam
  • To be in a resting position on a chair
  • To provide seating for people
  • To remain in a still position while being painted

site

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US / saɪt /

UK / saɪt /

A2
  • noun
  • Place that is reserved for a particular activity
  • Location of building work
  • Location of something
  • Place where something of special interest happened
  • Website
  • verb
  • To place something in a particular position, area

that

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US / ðæt /

UK / ðæt, ðət /

A1
  • adjecitve
  • The person or thing being talked about
  • Used to identify something both the speakers know
  • adverb
  • Used to reinforce adjectives and adverbs
  • To such a degree
  • conjunction
  • Used to connect a noun clause
  • Used to introduce an adverbial clause
  • Used to introduce a noun clause
  • determiner
  • Used as a noun to refer to something
  • pronoun
  • Referring an object far away
  • Used to refer to the relative pronoun ‘which’

what

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US / wɒt /

UK / hwɑt, hwʌt, wɔt, wʌt,hwət, wət /

A1
  • pronoun
  • Thing or things that; the same kind as
  • Used to emphasize something you are about to say
  • adjecitve
  • Used to refer to a particular amount, or number
  • Used to place emphasis on a particular quality
  • adverb
  • To a certain degree
  • determiner
  • Question words used for asking for information
  • exclamation
  • Used to express excitement, shock, or surprise
  • Used to ask people to repeat something they said

convolute

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US / ˈkɒnvəˌluːt /

UK / ˈkɑnvəˌlʊt /

A1
  • noun
  • Rolled longitudinally upon itself

end

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US / end /

UK / ɛnd /

A1
  • noun
  • The point where a process or activity stops
  • A point that marks the limit of something; finish
  • Goal or desired result
  • The tip, edge or limit of something
  • verb
  • To be the last part of something

remember

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US / rɪ'membə(r) /

UK / rɪˈmɛmbɚ /

A1
  • verb
  • To give someone a gift, e.g. birthday, wedding
  • To hold a thought in your mind to not forget it
  • To bring a previous image or idea to your mind

could

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US / kəd /

UK / kʊd /

A1
  • other
  • Past form of 'can' to mean have ability
  • Used to ask for something politely, or to offer

know

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US / nəʊ /

UK / noʊ /

A1
  • verb
  • To be familiar with a person or place, thing
  • To feel sure or be convinced about something
  • To discover or be aware of something
  • To be able to distinguish
  • To have knowledge of things

strand

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US / strænd /

UK / strænd /

B2
  • noun
  • Long part of a rope, someone's hair, etc.
  • A theme or topic area
  • verb
  • To cause to be stuck or trapped somewhere

group

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US / ɡru:p /

UK / ɡrup /

A1
  • noun
  • Two or more musicians who play music together
  • Number of people or things gathered together
  • verb
  • To combine or collect objects or people together

world

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US / wɜ:ld /

UK / wɜrld /

A1
  • noun
  • All the humans, events, activities on the earth
  • Political division due to some kind of similarity

draw

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US / drɔ: /

UK / drɔ /

A1
  • noun
  • Something that attracts people to visit a place
  • A lottery or prize
  • Result of a game, contest where the score is equal
  • verb
  • To attract attention to someone or something
  • To get closer to or approach something or someone
  • To influence a person's involvement in something
  • To move an object by pulling
  • To create an image using pen or pencil and paper
  • To take one thing out of a container, etc.
  • (Of 2 teams) to finish a game with the same score

see

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US / si: /

UK / si /

A1
  • verb
  • To go on a date with someone
  • To predict whether something is, or will be true
  • To understand what someone says
  • To use your eyes to look at something
  • To visit a place often for sightseeing or pleasure
  • To visit or meet with someone
  • To find out by waiting or looking
  • To watch (a game, movie or TV show)

subclass

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US / ˈsʌbklɑːs /

UK / ˈsʌbklæs /

B1
  • noun
  • A subgroup within a larger group

before

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US / bɪˈfɔ:(r) /

UK / bɪˈfɔr,-ˈfor /

A1
  • adverb
  • At a time earlier than the present; previously
  • conjunction
  • In advance of something happening
  • preposition
  • In front of someone or something

almost

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US / 'ɔ:lməʊst /

UK / ˈɔlˌmost, ɔlˈmost /

A1
  • adverb
  • Only a little less than, nearly, not quite

cock

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US / kɒk /

UK / kɑ:k /

C2
  • noun
  • Adult male chicken
  • A young man you find to be stupid or silly
  • A slang word for a penis

have

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US / həv /

UK / hæv /

A1
  • verb
  • To drink, smoke, eat or use something
  • To experience the effects of something
  • To organize an event, or join in an activity
  • To own, possess, or hold something
  • To cause to happen or produce a particular effect

part

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US / pɑ:t /

UK / pɑ:rt /

A1
  • adjecitve
  • To some degree; half; not fully
  • noun
  • Division of a book
  • Ratio of something, e.g. 3 of gin, 1 of tonic
  • A line in a person's hair, made with a comb
  • Character an actor plays on stage, movie, or TV
  • Some, but not all of a specific thing
  • Role in causing something to happen
  • verb
  • To make a line in a person's hair, by using a comb
  • To move two things apart creating a space
  • To leave someone, or to break off a relationship

conformation

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US / ˌkɒnfɔ:ˈmeɪʃn /

UK / ˌkɑ:nfɔ:rˈmeɪʃn /

B1
  • noun
  • Symmetrical arrangement of the parts of a thing

muscle

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US / 'mʌsl /

UK / ˈmʌsəl /

A2
  • noun
  • Physical power
  • Body tissue that moves parts of the body
  • verb
  • To use or muscles of force to get what you want

with

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US / wɪð /

UK / wɪð, wɪθ /

A1
  • preposition
  • As an employee of a certain company
  • Against something or someone
  • By using something as a means
  • Due to; because of
  • Including
  • Possessing as a feature
  • Related to
  • (Of the manner/attitude by which you do something)
  • Used to express that people or things are together

everyday

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US / ˈevrideɪ /

UK / ˈɛvriˈde /

A1
  • adjecitve
  • Used or seen daily; for daily use; ordinary

next

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US / nekst /

UK / nɛkst /

A1
  • adverb
  • The one that follows another in time or order
  • At a time or place directly after the present one
  • noun
  • The one that follows after
  • adjecitve
  • Immediately after the previous one
  • First occurrence after the present one
  • Subtitles section
  • What I want to do in this video is try to understand how two proteins can interact with each other in conjunction with ATP to actually produce mechanical motion.
  • And the reason why I want to do this, one, it occurs outside of muscle cells as well, but this is really going to be the first video on really how muscles work, and then we'll talk about how nerves actually stimulate muscles to work.
  • So it'll all build up from this video.
  • So what I've done here is I've copy and pasted two images of proteins from Wikipedia.
  • This is myosin.
  • It's actually myosin 2, because you actually have two strands of the myosin protein.
  • They're interwound around each other, so you can see it's this very complex-looking protein or enzyme, however you want to talk about it.
  • And I'll tell you why it's called an enzyme, because it actually helps react ATP into ADP and phosphate groups.
  • So that's why it's called an ATPase, or it's a subclass of the ATPase enzymes.
  • This right here is actin.
  • What we're going to see in this video is how myosin essentially uses the ATP to essentially crawl along.
  • You can almost view it as an actin rope, and that's what creates mechanical energy.
  • So let me draw it.
  • I'll actually draw it on this actin right here.
  • So let's say we have a myosin, one of these myosin heads.
  • So when I say a myosin head, this is one of the myosin heads right here.
  • And then it's connected.
  • It's intertwined, and it's wove around.
  • This is the other one, and it winds around that way.
  • Now let's just say we're just dealing with one of the myosin heads.
  • Let's say it's in this position.
  • Let me see how well I can draw it.
  • Let's say it starts off in a position that looks like that.
  • And then this is kind of the tail part that connects to some other structure.
  • And we'll talk about that in more detail.
  • But this is my myosin head right there in its starting position, not doing anything.
  • Now ATP can come along and bond to this myosin head, this enzyme, this protein, this ATPase enzyme.
  • So let me draw some ATP.
  • So let's say that ATP comes along and bonds to this guy right here.
  • So let's say that's the, and it's not going to be this big relative to the protein, but this is just to give you the idea.
  • So as soon as the ATP binds to its appropriate site on this enzyme or protein, the enzyme, it detaches from the actin.
  • So let me write this down.
  • So one, ATP binds to myosin head, and as soon as that happens, that causes the myosin to release actin.
  • So that's step one.
  • So I started off with this guy just touching the actin.
  • The ATP comes and it gets released.
  • So in the next step, so after that step, it's going to look something like this.
  • And I want to draw it kind of in the same place.
  • So after the next step, it's going to look something like this.
  • It will have released.
  • So now, let me shade it in with the white.
  • So now it looks something like that.
  • And you have the ATP attached to it still.
  • I know it might be a little bit convoluted when I keep writing over the same thing, but you have the ATP attached to it.
  • Now the next step, the ATP hydrolyzes.
  • The phosphate gets pulled off of it.
  • This is an ATPase enzyme.
  • That's what it does.
  • So let me write that down.
  • So step two, let me scroll down a little bit.
  • Step two, ATP goes to ADP plus a phosphate group.
  • And what that does, that releases the energy to cock this myosin protein into kind of a high energy state.
  • So let me do step two.
  • So step two, this thing, it gets hydrolyzed.
  • It releases energy.
  • We know that ATP is the energy currency of biological systems.
  • So let me draw it.
  • So it releases energy.
  • I'm drawing it as like a little spark or explosion.
  • But you can really imagine it as it's changing the conformation of, it kind of spring loads this protein right here to go into a state so it's ready to kind of crawl along the myosin.
  • So in step two, so plus energy, and then this, you can kind of say it cocks the myosin protein or enzyme to high energy.
  • Can I kind of imagine it kind of winds the spring or loads the spring to high energy conformation.
  • And conformation for proteins just means shape.
  • So step two, what happens is the phosphate group gets, they're still attached, but it gets detached from the rest of the ATP, so that becomes ADP, and then that energy changes the conformation so that this protein now goes into a position that looks like this.
  • And let me draw it like, so this is where we end up at the end of step two.
  • Let me make sure I do it right.
  • So at the end of step two, it might look something like this.
  • I'm trying my best to draw it.
  • So at the end of step two, the protein looks something like this.
  • This is kind of in its cocked position.
  • It has a lot of energy right now.
  • It's kind of wound up in this position.
  • You still have your ADP, that's your adenosine, and then let's say you have your two phosphate groups on the ADP, and you still have one phosphate group right there.
  • Now, when that phosphate group releases, so then let me write this as step three.
  • So remember, when we started, we were just sitting here.
  • At the ATP kind of binds on step one, or actually it does definitely bind, at the end of step one, that causes the myosin protein to get released.
  • Then after step one, we get, well, we naturally have step two.
  • The ATP hydrolyzes into ADP phosphate.
  • That releases energy, and that allows the myosin protein to get cocked into this high energy position and kind of attach, you can kind of think of it, to the next rung of our actin filament.
  • Now we're ready to kind of, we're in a high energy state when, let me write this down, in step three, the phosphate releases, released from myosin.
  • The phosphate is released from myosin in step three.
  • That's step three right there.
  • That's a phosphate group being released.
  • And what this does is this releases that energy of that cocked position, and it causes this myosin protein to push on the actin.
  • This is the power stroke, if you imagine it in an engine.
  • This is what's causing the mechanical movement.
  • So when the phosphate group is actually, remember, the original release is when you take ATP to ADP in a phosphate.
  • That put it in this kind of spring-loaded position.
  • When the phosphate releases it, this releases the spring.
  • And what that does is it pushes on the actin filament.
  • So you could view this as the power stroke.
  • We're actually creating mechanical energy.
  • So depending on which one you want to view as fixed, if you view the actin as fixed, whatever myosin is attached to would move to the left.
  • If you imagine the myosin being fixed, then whatever the actin and whatever it's attached to would move to the right, either way.
  • But this is where we fundamentally get the muscle action.
  • And then step four, you have the ADP released.
  • And then we're exactly where we were before we did step one, except we're just one rung further to the left on the actin molecule.
  • So to me, this is pretty amazing.
  • We actually are seeing how ATP energy can be used to, we're going from chemical energy.
  • Let me write that down.
  • We're going from chemical energy or bond energy in ATP to mechanical energy.
  • And for me, that's amazing, because when I first learned about ATP and people say, oh, you use ATP to do everything in your cells and contract muscles, I thought, well, gee, how do you go from bond energy to actually contracting things to actually doing what we see in our everyday world as mechanical energy?
  • And this is really where it all occurs.
  • This is really the core issue that's going on here.
  • And you have to say, well, gee, how does this thing change shape and all of that?
  • And you have to remember, these proteins, based on what's bonded to it and what's not bonded to it, they change shape, and some of those shapes take more energy to attain, and then if you kind of do the right things,
  • That energy can be released, and then it can push another protein.
  • But I find this just fascinating.
  • And now we can build up from this actin and myosin interactions to understand how muscles actually work.